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Both metformin and semaglutide are FDA-approved to treat type 2 diabetes — but their uses don't stop there. Metformin is often prescribed off-label for managing gestational diabetes, polycystic ovary syndrome (PCOS), and

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Pooled data from the STEP-HFpEF and STEP-HFpEF DM trials (totaling 1,145 participants) corroborated these findings: semaglutide led to significant increases in KCCQ-CSS scores, body weight reduction and improvements in secondary endpoints, including the 6MWD and inflammation markers [96]