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Companies in this space include mitochondrial uncouplers with enhanced safety profiles (Rivus, Continuum), GDF15 targeting drugs (Novo, Lilly, Janssen), anti- activin II receptor mAb (Versanis), mir-22 inhibition (Resalis Tx) and gut-brain axis modulators (Kallyope)
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In the future, innovation may focus on five key areas: long-acting formulations, oral delivery methods, multi-target combination therapies, and expanding the range of indications
