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Furthermore, exendin-4 can cross the blood-brain barrier (Kastin and Akerstrom, 2003) and has a neuroprotective role in some neurological disorders (Holscher, 2010
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9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemm’s canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow
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